The Recombinant Vaccine against Human Chorionic Gonadotropin goes on Combined Immunogenicity, Safety and Efficacy Clinical Trials
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چکیده
منابع مشابه
Safety and immunogenicity of recombinant human thrombin: a pooled analysis of results from 10 clinical trials.
STUDY OBJECTIVE To evaluate the safety and immunogenicity of recombinant human thrombin (rThrombin), an active topical stand-alone hemostatic agent. DESIGN Analysis of pooled data from 10 rThrombin clinical trials. PATIENTS A total of 644 adult and pediatric patients treated with rThrombin; 609 patients were included in the immunogenicity analysis. MEASUREMENTS AND MAIN RESULTS In all stu...
متن کاملThe efficacy of human chorionic gonadotropin in retractile testis.
OBJECTIVES To evaluate the efficacy of hCG therapy on retractile testis in various testicular locations and age groups. SETTING AND DESIGN This study comprised 123 boys whose diagnosis were retractile testis with scrotal base, high scrotal and superficial inguinal localizations with an average age of 4,2 (1-8) years. METHODS 123 boys with retractile testes were given a total dose of 9000 hC...
متن کاملRecombinant or urinary human chorionic gonadotropin in ovulation induction?
The onset of the spontaneous LH surge in women is relatively abrupt with concentrations doubling within 2 h to between 100 and 200 IU/l being sustained for 12–14 h over a mean duration of 50 h [1]. This mid-cycle surge, in addition to follicular rupture [2], promotes several periovulatory events including disruption of the oocyte– cumulus oophorus cell contact and induction of the resumption of...
متن کاملSingle‐dose pharmacokinetic study comparing the pharmacokinetics of recombinant human chorionic gonadotropin in healthy Japanese and Caucasian women and recombinant human chorionic gonadotropin and urinary human chorionic gonadotropin in healthy Japanese women
Purpose Recombinant hCG (r-hCG) was approved in Japan in 2016. As a prerequisite for a Phase III study in Japan related to this approval, the pharmacokinetic (PK) profile of r-hCG was investigated. Methods An open-label, partly randomized, single-center, single-dose, group-comparison, Phase I PK-bridging study was done that compared a single 250 μg dose of r-hCG with a single 5000 IU dose of ...
متن کاملHuman Chorionic Gonadotropin
A highly active preparation of human chorionic gonadotropin has been obtained by simple methods of column chromatography on diethylaminoethyl Sephadex and Sephadex G-100. The preparation appeared homogeneous by disc and immunoelectrophoresis, ultracentrifugation, and end group analysis. It assayed at 12,000 i.u. per mg by the rat prostrate gland and accessory sex organ method. The ~20,~ value w...
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ژورنال
عنوان ژورنال: Global Journal of Reproductive Medicine
سال: 2018
ISSN: 2575-8594
DOI: 10.19080/gjorm.2018.05.555654